3. If salicylic acid is present, the test will turn a deep purple color, Add all chemicals to the round-bottomed flask and setup the heating bath. The synthesis reaction of aspirin is shown below: The spectroscopic analysis of aspirin will involve the complexing of iron(III) to the deprotonated form of.

H 2 SO 4 (use a dropper, H2SO4 is highly corrosive) and swirl the flask gently until the salicylic acid dissolves. Only the salicylate ion complexes to iron(III). The chemical equation for the synthesis of aspirin is C7H6O3 + C4H6O3 –> C9H8O4 +C2H4O2, which is a reaction of salicylic acid with acetic anhydride in the presence of phosphoric acid. %PDF-1.5 �gz�܁]"��K�e]��u�H1�1��6p�����7��^}�{J��0HL��ϔ�|���#f_�j �b���r�z���g���O��C�B+y�L�5�U�P�����&pQ8)�6yr�G�d)ʢ ��B�虼wy��@�*��M����ċ{R�x]��O�#�-��r=U���]G�nH�& #����g>V��DV l�V-�E�@�Kxk�T[�o�k���z��A�V�B�dA�{e�!G��y�OUl}|�ve,59�[�0��s�;�-�/��+�������r-�SH��� ��**��h-��%�� Ҫ�]�(� 3.0 g salicylic acid; 6 mL acetic anhydride* 5-8 drops of 85% phosphoric acid or concentrated sulfuric acid* Distilled water (about 50 mL) 10 mL ethanol; 1% iron III chloride (optional, to test purity) *Use extreme caution when handling these chemicals. After synthesis, the sample will be purified by recrystallization meth-ods. z�`�U�3lj }�x~&�������DM�?������n endobj

In thisexperiment, phosphoric acid will be used as the catalyst. Aspirin or ASA (acetylsalicylic acid) can be synthesized by turning the hydroxyl group of salicylic acid into an ester group (R-OH → R-OCOCH, In the body, however, aspirin is again metabolized to salicylic acid, which is the active ingredient, The product can be tested for purity, by adding ferric chloride to an aqueous solution.

The excess acetic acid will be quenched with, the addition of water. The byproduct is acetic acid.

Add 5 mL (0.05 mole) of acetic anhydride, followed by 5 drops of conc. endobj The molecular geometry of aspirin is planar and its molecular mass is 180.159 g/mol. 4. <>>> In this, experiment, phosphoric acid will be used as the catalyst.

Aspirin, or acetylsalicylic acid, is one of the oldest and most common medications worldwide.

Aspirin or ASA (acetylsalicylic acid) can be synthesized by turning the hydroxyl group of salicylic acid into an ester group (R-OH → R-OCOCH 3) In the body, however, aspirin is again metabolized to salicylic acid, which is the active ingredient; The product can be tested for purity, by adding ferric chloride to an aqueous solution. Reagent A – Weigh 1.00 g of the aspirin product into a 50 mL beaker. � F�5:t�5VH2?�sb8c.���w��%Wp���[0�FL��f.upqG1�9�}j�s�����ߍ-�áWi�<�|Ĕ�S ���ZkϹ�*��.Ƃ�̩.

Festival of Sacrifice: The Past and Present of the Islamic Holiday of Eid al-Adha. A small amount of a strong acid is used as a catalyst that speeds up the reaction. Add 10 mL of <>/XObject<>/ExtGState<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> Do not use a Bunsen burner because ethanol is flammable. Once aspirin is synthesized, it needs to be purified, and an estimation of its purity should be performed. *6A�8y�=nI)�!��[rSo���i4YO�D���^�I�,�|�L���GZ�8��K�j�O�� Is the Coronavirus Crisis Increasing America's Drug Overdoses? The aspirin product is not very soluble in water so the aspirin product will. Here is how to make Aspirin yourself: Aspirin is the common name for the compound acetylsalicylic acid, widely used as a fever reducer and asa pain killer.

The structural formula of aspirin or Acetylsalicylic acid is represented as- Aspirin is extensively used in the pharmaceutical sector.

Heat the water bath to boiling and keep it at this temperature for around 10 minutes, Add 2ml of distilled water to destroy remaining acetic anhydride. Preparing Aspirin is a classic lab synthesis performed in university and school. The reaction for the synthesis is given below. 4 0 obj Adding cold water stops the reaction, and the products are filtered, yielding aspirin.

The results section will present all the numerical data necessary for this experi-ment (synthesis of aspirin masses, theoretical yield, percent yield and error, and TLC analysis). The excess acetic acid will be quenched withthe addition of water. The byproduct is acetic acid. The most common way to prepare aspirin is by using Acid Anhydrides and by reacting acetic acid with salicylic acid. <> <> endobj H 3PO 4 C 4H 6O 3 + C 7H 6O 3 → C 9H 8O 4 + HC 2H 3O 2 Acetic Salicylic Aspirin Acetic Acid Anhydride Acid This can be expanded to the following structures: Note: Carbons (and hydrogens) are implied where lines (bonds) meet. The aspirin product is not very soluble in water so the aspirin product willprecipitate when water is added. salicylic acid (salicylate ion) to give a purple solution. ), The Secret Science of Solving Crossword Puzzles, Racist Phrases to Remove From Your Mental Lexicon. If salicylic acid is present, the test will turn a deep purple color ����zV��e �,r��}�CCM9���nP�"���ST>4 3 0 obj Will 5G Impact Our Cell Phone Plans (or Our Health?! First, gather the chemicals and equipment used to synthesize the aspirin. The synthesis reaction of aspirin is shown below: The spectroscopic analysis of aspirin will involve the complexing of iron(III) to the deprotonated form ofsalicylic acid (salicylate ion) to give a purple solution. To prepare aspirin, salicylic acid is reacted with an excess of aceticanhydride. Add 10 mL of ethanol and gently warm the mixture on a hot plate to dissolve. What Is the Chemical Equation for the Synthesis of Aspirin. A “purified product” can be obtained through recrystallization of the crude product in hot, Aspirin is the common name for the compound acetylsalicylic acid, widely used as a fever reducer and as, a pain killer. Add a magnetic stirring bar to the flask and begin heating the mixture. 1Taken fromSynthesis and Analysis of Aspirin, UCLA Chemistry Department. Transfer 20 drops of this aspirin-ethanol solution into tube A.

A small amount of a strong acid is used as a catalyst that speeds up the reaction. Aspirin Synthesis Materials . As the solution cools, crystals of aspirin will appear. 1 0 obj %����
After a minute, remove the flask from the water bath and add 20 mL of distilled water. The reaction, using molecular formulas is C7H6O3 + C4H6O3 --> C9H8O4 …

Let the flask cool to room temperature. It is used to treat pain, reduce fever, and to decrease the aggregation of platelets, such as to decrease blood clotting. Page 2 of 5 Warning: The aspirin …

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Reagent B – Weigh 1.00 g of the crushed aspirin tablet into a 50 mL beaker. Salicylic acid, whose name comes from Salix, the willow family of plants, was derived fromwillow bark extracts.

Zn&�O���*= �X�*�(�̟��ݽ�*'�+}1���64�l��R�UI�������٬���}v!�!�^G�b5U�n_�b�D^�H�[�����?���X�Z,���9�e&���Z�hg}V��A�s��M�98�AX����� Only the salicylate ion complexes to iron(III). stream Salicylic acid, whose name comes from Salix, the willow family of plants, was derived from, To prepare aspirin, salicylic acid is reacted with an excess of acetic, anhydride. x��Z�n�F}7��G)���xxn� 6���0�-�YVHN�7����i���X�/Wo�����׫ۗMq�)(�yS>�g3���[������J2���gJH�_�ȄA��H! equation is displayed below. The chemical equation for the synthesis of aspirin is C7H6O3 + C4H6O3 –> C9H8O4 +C2H4O2, which is a reaction of salicylic acid with acetic anhydride in the presence of phosphoric acid. precipitate when water is added. e�:{�L���DR��d{։�����Hd��)B�! Fact Check: What Power Does the President Really Have Over State Governors? 2 0 obj SYNTHESIS OF ASPIRIN (acetylsalicylic acid) Place 2.0 g (0.015 mole) of salicylic acid in a 125-mL Erlenmeyer flask. For the synthesis of aspirin, how do you calculate the percent yield if the reaction produces 4.70 grams of aspirin. �.�T� Z��S@xM���.��� C��P�;}�bW-u۞^�,��h���,i� lj�cV�2 dҷ���(H�7�g^p��H0'�~T I�@�%Rp��NK\� ���:�.CL�@�ԋM�j{s�woa�_��<3���T��{��m����2f�k^@�ao��I#Ț�%�xl���E-�n����&�K�UF�+���m�����Ș ��Ƕ9����k�ź���ޠ�X_M/]G���.��m_���歝�p��o��� �� The purity of the sample will then be ana-lyzed using TLC.

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